SKF-39315

SKF-39315
	File:SKF-39315.svg
Clinical data
Other names	SKF39315; SKF-39315A; SK&F-39315A
Identifiers
	IUPAC name 2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;
CAS Number	138355-28-9;
PubChem CID	10058098;
ChemSpider	8233652;
ChEMBL	ChEMBL57873;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C10H13NO2
Molar mass	179.219 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CNCCC2=CC(=C(C=C21)O)O;
	InChI InChI=1S/C10H13NO2/c12-9-5-7-1-3-11-4-2-8(7)6-10(9)13/h5-6,11-13H,1-4H2; Key:LPJMTSQTVDKBCO-UHFFFAOYSA-N;

SKF-39315 is a monoamine receptor modulator of the 3-benzazepine family.^[1] It is a cyclized phenethylamine analogue of the neurotransmitter dopamine.^[1] The drug shows affinities (K_i) of 12 nM for the dopamine D₂ receptor and 5,200 nM for the dopamine D₁ receptor.^[1] It also has direct and indirect adrenergic actions.^[1] The 1-phenyl derivative of SKF-39315 is SKF-38393, which has reversed activities at dopamine receptors compared to SKF-39315 and acts as a selective dopamine D₁-like receptor agonist.^[1] SKF-39315 was first described in the scientific literature by at least 1988.^[1]

References

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