Butopamine

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Butopamine
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Clinical data
Other names
  • LY-131126
  • (R,R)-Ractopamine
Drug classSympathomimetic; β-Adrenergic receptor agonist; Positive inotrope; Positive chronotrope
Identifiers
  • 4-[(3R)-3-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]butyl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC18H23NO3
Molar mass301.386 g·mol−1
3D model (JSmol)
  • C[C@H](CCC1=CC=C(C=C1)O)NC[C@@H](C2=CC=C(C=C2)O)O
  • InChI=1S/C18H23NO3/c1-13(2-3-14-4-8-16(20)9-5-14)19-12-18(22)15-6-10-17(21)11-7-15/h4-11,13,18-22H,2-3,12H2,1H3/t13-,18+/m1/s1
  • Key:YJQZYXCXBBCEAQ-ACJLOTCBSA-N

Butopamine (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code name LY-131126; also known as (R,R)-ractopamine) is a sympathomimetic agent, β-adrenergic receptor agonist, and positive inotrope of the phenethylamine family which was studied for treatment of heart failure but was never marketed.[1][2][3][4] It is an analogue of dobutamine[3][4] and is the (R,R)-enantiomer of ractopamine.[2] Butopamine is not a catecholamine and is resistant to metabolism by catechol O-methyltransferase (COMT).[3] In contrast to dobutamine, butopamine is orally active.[3] In addition to its positive inotropic effects, butopamine has positive chronotropic effects.[3]

References

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