Cericlamine

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Cericlamine
Clinical data
Other namesJO-1017
Routes of
administration		Oral[1]
ATC code
  • None
Pharmacokinetic data
Elimination half-life8 hours[1]
Identifiers
  • 3-(3,4-Dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol
CAS Number
PubChem CID
ChemSpider
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC12H17Cl2NO
Molar mass262.17 g·mol−1
3D model (JSmol)
  • CC(CC1=CC(=C(C=C1)Cl)Cl)(CO)N(C)C
  • InChI=1S/C12H17Cl2NO/c1-12(8-16,15(2)3)7-9-4-5-10(13)11(14)6-9/h4-6,16H,7-8H2,1-3H3
  • Key:FWYRGHMKHZXXQX-UHFFFAOYSA-N

Cericlamine (INN; developmental code JO-1017) is a potent and moderately selective serotonin reuptake inhibitor (SSRI) of the amphetamine family (specifically, a derivative of phentermine, and closely related to chlorphentermine, a highly selective serotonin releasing agent) that was investigated as an antidepressant for the treatment of depression, anxiety disorders, and anorexia nervosa by Jouveinal but did not complete development and was never marketed.[1][2][3][4] It reached phase III clinical trials in 1996 before development was discontinued in 1999.[5]

According to Czech scientists, cericlamine is claimed to be part of a highly advanced “fifth generation” of antidepressants as was venlafaxine.[6]

The daily dosage was reported to be 300mg.[1]

See also

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References

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