Isoproscaline
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| Clinical data | |
|---|---|
| Other names | 4-Isopropoxy-3,5-dimethoxyphenethylamine |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Pharmacokinetic data | |
| Duration of action | 10–16 hours[1] |
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| PubChem CID | |
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| ChEMBL | |
| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C13H21NO3 |
| Molar mass | 239.315 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 163 to 164 °C (325 to 327 °F) (hydrochloride) |
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Isoproscaline or 4-isopropoxy-3,5-dimethoxyphenethylamine is an analogue of mescaline.[1] It is closely related to proscaline and was first synthesized by David E. Nichols and colleagues.[2] It produces psychedelic effects.
Use and effects
[edit | edit source]Little is known about the psychopharmacological effects of isoproscaline. In his book PiHKAL, Alexander Shulgin lists a psychedelic dose as being 40–80 mg, with effects lasting 10–16 hours.[1]
Interactions
[edit | edit source]Pharmacology
[edit | edit source]Pharmacodynamics
[edit | edit source]The mechanism that produces the hallucinogenic and entheogenic effects of isoproscaline is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines.[citation needed]
Chemistry
[edit | edit source]Isoproscaline is in a class of compounds commonly known as phenethylamines, and the full chemical name is 2-(4-isopropoxy-3,5-dimethoxyphenyl)ethanamine.[1]
Synthesis
[edit | edit source]The chemical synthesis of isoproscaline has been described.[1]
Analogues
[edit | edit source]Analogues of isoproscaline include mescaline, escaline, proscaline, allylescaline, and methallylescaline, among others.[1]
Society and culture
[edit | edit source]Legal status
[edit | edit source]Isoproscaline is unscheduled in the United States; however, because of its close similarity in structure and effects to mescaline, possession and sale of isoproscaline may be subject to prosecution under the Federal Analog Act.
In the UK, its highly likely that this compound would be covered by the "phenylethylamine amendment" to the misuse of drugs act likely rendering it a Class A controlled drug.