In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists metaescaline's dose as 200 to 350mg orally and its duration as 8 to 12hours.[1] Its onset was described as slow and ranged from 0.5 to 1.5hours.[1] The drug's potency is similar to that of mescaline.[1][2]
The effects of metaescaline were reported to include brightening of colors, mildly heightened visual awareness and quite heightened auditory awareness, no closed-eyeimagery to significant closed-eye visuals, visual distortions such as walls dissolving, thinking changes, associative thinking, introspection, and insights.[1] Other effects included a "marvelous feeling inside", euphoria, feeling energetic, easy talking and talkativeness, relaxation, disinhibition, feeling connected and bonded with others, and subjective effects being more based in feelings than cognitive.[1] No hangover was reported.[1] It was said that no one was reluctant to repeat the experience.[1]Alcohol was reported to potentiate or rekindle the effects of metaescaline in a TOMSO-like manner in one report.[1]
Metaescaline was variously described as a "sterner mescaline" and as "not dramatic like some psychedelics".[1] Unlike mescaline or peyote, there was little body discomfort, no nausea, and only occasional hyperreflexia.[1] In addition, metaescaline was said to have less exaggeration of color perception than mescaline and that music was associated with little imagery in contrast to mescaline.[1] The transference characteristic of MDMA were said to be basically absent, but it was felt that metaescaline might nonetheless be useful for psychedelic-assisted psychotherapy purposes.[1]
Metaescaline was mentioned in the literature by Abram Hoffer and Humphrey Osmond in their 1967 book The Hallucinogens.[3] It was subsequently described by Alexander Shulgin and Peyton Jacob III in 1984.[2] Following this, metaescaline was described in greater detail by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1]
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