Mevidalen

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Mevidalen
Clinical data
Other namesLY-3154207; LY3154207
Routes of
administration		By mouth
Identifiers
  • 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
CompTox Dashboard (EPA)
  • {{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
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Chemical and physical data
FormulaC24H29Cl2NO3
Molar mass450.40 g·mol−1
3D model (JSmol)
  • C[C@H]1C2=CC=CC(=C2C[C@@H](N1C(=O)CC3=C(C=CC=C3Cl)Cl)CO)CCC(C)(C)O
  • InChI=1S/C24H29Cl2NO3/c1-15-18-7-4-6-16(10-11-24(2,3)30)19(18)12-17(14-28)27(15)23(29)13-20-21(25)8-5-9-22(20)26/h4-9,15,17,28,30H,10-14H2,1-3H3/t15-,17+/m0/s1
  • Key:XHCSBQBBGNQINS-DOTOQJQBSA-N

Mevidalen (LY-3154207) is a dopaminergic drug which is under development for the treatment of Lewy body disease, including those with Parkinson's disease.[1][2][3][4][5]

It acts as a selective positive allosteric modulator (PAM) of the dopamine D1 receptor.[1][6] The drug is orally active and crosses the blood–brain barrier.[6] It is a tetrahydroisoquinoline and is a close analogue of DETQ, another D1 receptor PAM.[2][3][6]

Mevidalen has been found to have wakefulness-promoting effects in sleep-deprived humans.[7][8] Side effects of mevidalen have been reported to include increased heart rate and blood pressure, insomnia, dizziness, nausea, vomiting, anxiety, fatigue, headaches, palpitations, and contact dermatitis, as well as falls in those with dementia.[6][5][8]

As of November 2023, mevidalen is in phase II clinical trials for the treatment of Lewy body disease.[1] Besides for movement disorders and dementia, D1 receptor PAMs like mevidalen might have value in the treatment of certain neuropsychiatric disorders, such as depression, hypersomnolence, and attention deficit hyperactivity disorder (ADHD).[2]

See also

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References

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