CHF-1024

CHF-1024
Clinical data
Other names	CHF1024; 5,6-Dihydroxy-2-methylaminotetralin
Drug class	Dopamine D2 recpetor agonist; α2-Adrenergic receptor agonist
ATC code	None;
Identifiers
	IUPAC name 6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diol;
CAS Number	39478-89-2;
PubChem CID	38005;
ChemSpider	34840;
UNII	045Q4E2K14;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C11H15NO2
Molar mass	193.246 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC1CCC2=C(C1)C=CC(=C2O)O;
	InChI InChI=1S/C11H15NO2/c1-12-8-3-4-9-7(6-8)2-5-10(13)11(9)14/h2,5,8,12-14H,3-4,6H2,1H3; Key:BHDFPNRSDABMPW-UHFFFAOYSA-N;

CHF-1024, also known as 5,6-dihydroxy-2-methylaminotetralin, is a dopamine D₂ receptor agonist and α₂-adrenergic receptor agonist of the 2-aminotetralin family.^[1]^[2] It is a cyclized phenethylamine analogue of the neurotransmitter dopamine.^[1] The drug is the active form of nolomirole (CHF-1035), a prodrug of CHF-1024 and the N,N-diisobutyryl diester of the compound.^[1]^[2] Nolomirole was investigated for the treatment of heart failure but was never marketed.^[1]^[2]

References

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