Isometheptene

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Isometheptene
Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa601064
Routes of
administration		Oral
ATC code
Identifiers
  • N,6-Dimethylhept-5-en-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC9H19N
Molar mass141.258 g·mol−1
3D model (JSmol)
  • CNC(C)CCC=C(C)C
  • InChI=1S/C9H19N/c1-8(2)6-5-7-9(3)10-4/h6,9-10H,5,7H2,1-4H3 checkY
  • Key:XVQUOJBERHHONY-UHFFFAOYSA-N checkY
  (verify)

Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins).[1][2] Along with paracetamol and dichloralphenazone, it is one of the constituents of Amidrine.

Chemistry

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Isometheptene is a monounsaturated aliphatic secondary amine.

Mechanism of action

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Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.[3]

See also

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References

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