PRDM2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[1][2]
Function
[edit | edit source]This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[2]
Interactions
[edit | edit source]PRDM2 has been shown to interact with Estrogen receptor alpha[3] and Retinoblastoma protein.[1]
References
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Further reading
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External links
[edit | edit source]- PRDM2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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