NKX-homeodomain factors are a family of homeodomain transcription factors that are critical regulators of organ development.[1]
Human genes that encode NKX-homeodomain factors include:
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(1) Basic domains |
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| (1.1) Basic leucine zipper (bZIP) | |
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| (1.2) Basic helix-loop-helix (bHLH) | | Group A | |
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| Group B | |
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Group C
bHLH-PAS | |
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| Group D | |
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| Group E | |
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Group F
bHLH-COE | |
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| (1.3) bHLH-ZIP | |
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| (1.4) NF-1 | |
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| (1.5) RF-X | |
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| (1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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| (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
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| subfamily 2 | |
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| subfamily 3 | |
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| subfamily 4 | |
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| subfamily 5 | |
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| subfamily 6 | |
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| subfamily 0 | |
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| (2.2) Other Cys4 | |
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| (2.3) Cys2His2 | |
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| (2.4) Cys6 | |
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| (2.5) Alternating composition | |
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| (2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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