HOXB5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[1][2][3]
Function
[edit | edit source]This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[3]
See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- HOXB5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P02833 (Drosophila melanogaster Homeotic protein antennapedia) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
