CEBPD

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.

See also

• Ccaat-enhancer-binding proteins

External links

• Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser.
• CEBPD+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.