Sterol regulatory element–binding protein 2

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.

Function

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain. Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis.

Interactions

SREBF2 has been shown to interact with INSIG1 and the CREB-binding protein.

See also

• Sterol regulatory element-binding protein

External links

• SREBF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook SREBP2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.