ARID1B
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene.[1] ARID1B is a component of the human SWI/SNF chromatin remodeling complex.
Clinical significance
[edit | edit source]Germline mutations in ARID1B are associated with Coffin–Siris syndrome.[2][3] Somatic mutations in ARID1B are associated with several cancer subtypes, suggesting that it is a tumor suppressor gene.[4][5][6][7]
Interactions
[edit | edit source]ARID1B has been shown to interact with SMARCA4[8][9] and SMARCA2.[9]
References
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Further reading
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External links
[edit | edit source]- ARID1B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human ARID1B genome location and ARID1B gene details page in the UCSC Genome Browser.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.