CBFA2T2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.[1][2]
Function
[edit | edit source]In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.[2]
Interactions
[edit | edit source]CBFA2T2 has been shown to interact with RUNX1T1.[3][4][5]
References
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Further reading
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External links
[edit | edit source]- CBFA2T2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CBFA2T2 genome location and CBFA2T2 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
