HOXB8
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3]
Function
[edit | edit source]This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the hair-pulling behavior of humans suffering from trichotillomania (TTM).[3]
Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results in a reduction of compulsive grooming.[4]
See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- HOXB8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
