MSP-1014

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MSP-1014
Clinical data
Other namesMSP1014; MSP-1014.OX
Routes of
administration		Oral[1][2]
Drug classSerotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
Identifiers
E number{{#property:P628}}
CompTox Dashboard (EPA)
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MSP-1014 is a serotonergic psychedelic which is under development for the treatment of major depressive disorder, other depressive disorders, and anxiety disorders.[3][4][5][1][2]

It is a prodrug of psilocin similarly to psilocybin, and hence acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor.[3][5][2][6]

The drug is under development by Mindset Pharma and Otsuka America Pharmaceutical.[3][4][5] As of January 2024, it is in phase 2 clinical trials for major depressive disorder and is in the preclinical stage of development for anxiety disorders and other depressive disorders.[3][4][5] The chemical structure of MSP-1014 does not yet seem to have been disclosed.[3][4] However, Mindset Pharma patented psilocin derivatives and prodrugs in 2022.[7]

See also

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References

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  1. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  2. ^ a b c Araujo JA, Higgins GA, de Lannoy IA, Dean I, Atkinson J, Lanthier J, Slassi M. (2022 November 13). 147.05 / JJ5 - The preclinical safety, behavioural and pharmacokinetics properties of MSP-1014, a novel prodrug of psilocin. Neuroscience 2022. https://www.abstractsonline.com/pp8/#!/10619/presentation/70912
  3. ^ a b c d e Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  4. ^ a b c d Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  5. ^ a b c d Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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  7. ^ US 2022/0289774, Slassi A, Araujo J, "Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders", issued Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to Mindset Pharma Inc. 
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