Capeserod

Capeserod
Clinical data
ATC code	None;
Identifiers
	IUPAC name 5-(5-Amino-6-chloro-2,3-dihydro-1,4-benzodioxin-8-yl)-3-[1-(2-phenylethyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one;
CAS Number	769901-96-4 ; 191023-43-5 (HCl);
PubChem CID	9805719;
IUPHAR/BPS	29;
ChemSpider	7981479;
UNII	8163770L8P;
ChEMBL	ChEMBL2027925;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C23H25ClN4O4
Molar mass	456.93 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCC1N2C(=O)OC(=N2)C3=CC(=C(C4=C3OCCO4)N)Cl)CCC5=CC=CC=C5;
	InChI InChI=1S/C23H25ClN4O4/c24-18-14-17(20-21(19(18)25)31-13-12-30-20)22-26-28(23(29)32-22)16-7-10-27(11-8-16)9-6-15-4-2-1-3-5-15/h1-5,14,16H,6-13,25H2; Key:MDBNTXARNGRHEV-UHFFFAOYSA-N;

Capeserod (INN;^[1] development code SL65.0155) is a selective 5-HT₄ receptor partial agonist with K_i = 0.6 nM and IA = 40–50% (relative to serotonin).^[2] It potently enhances cognition, learning, and memory,^[2]^[3]^[4]^[5]^[6]^[7] and also possesses antidepressant effects.^[8] Capeserod was in phase II clinical trials around 2004–2006 for the treatment of memory deficits and dementia but no new information has surfaced since and it appears to have been abandoned.^[9]^[10]

References

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This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

v t e Psychoanaleptics: Anti-dementia agents (ATC code N06D and others)
AChE inhibitor medications	Benzgalantamine Donepezil (+memantine) Galantamine Ipidacrine Rivastigmine Tacrine
Other medications	Aducanumab Bifemelane Donanemab Ginkgo folium Lecanemab Meclofenoxate (centrophenoxine) Memantine (+donepezil) Nicergoline
Experimental BACE inhibitors	Lanabecestat Verubecestat

Clinical data

ATC code	None
Identifiers
IUPAC name 5-(5-Amino-6-chloro-2,3-dihydro-1,4-benzodioxin-8-yl)-3-[1-(2-phenylethyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one
CAS Number	769901-96-4 191023-43-5 (HCl)
PubChem CID	9805719
IUPHAR/BPS	29
ChemSpider	7981479
UNII	8163770L8P
ChEMBL	ChEMBL2027925
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₃H₂₅ClN₄O₄
Molar mass	456.93 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1N2C(=O)OC(=N2)C3=CC(=C(C4=C3OCCO4)N)Cl)CCC5=CC=CC=C5
InChI InChI=1S/C23H25ClN4O4/c24-18-14-17(20-21(19(18)25)31-13-12-30-20)22-26-28(23(29)32-22)16-7-10-27(11-8-16)9-6-15-4-2-1-3-5-15/h1-5,14,16H,6-13,25H2 Key:MDBNTXARNGRHEV-UHFFFAOYSA-N