CTW0404

CTW0404
Identifiers
	IUPAC name (2S,4R)-N-(2-morpholin-4-ylethyl)-4-(2-phenylethyl)piperidine-2-carboxamide;
PubChem CID	156012687;
ChemSpider	129472747;
ChEMBL	ChEMBL4637675;
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).;
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C20H31N3O2
Molar mass	345.487 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN[C@@H](C[C@@H]1CCC2=CC=CC=C2)C(=O)NCCN3CCOCC3;
	InChI InChI=1S/C20H31N3O2/c24-20(22-10-11-23-12-14-25-15-13-23)19-16-18(8-9-21-19)7-6-17-4-2-1-3-5-17/h1-5,18-19,21H,6-16H2,(H,22,24)/t18-,19+/m1/s1; Key:YQSGRDPBXKGAPX-MOPGFXCFSA-N;

CTW0404 is an experimental drug which is described as a positive allosteric modulator of the 5-HT_2A receptor, with neutral or negative modulation of the related 5-HT_2B and 5-HT_2C subtypes. It does not produce the head-twitch response in animal studies, and reduces the head-twitch response produced by DOI, suggesting that it may be a biased allosteric modulator selective for certain signalling pathways.^[1]^[2]^[3]^[4]

References

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^ WO 2023/023287, Zhou J, Cunningham KA, Bolinger AA, Anastasio NC, "Novel heterocyclic compounds as serotonin (5-ht) 5-ht2a and 5-ht2c receptor positive allosteric modulators.", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Board of Regents of the University of Texas System

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[4] WO 2023/023287, Zhou J, Cunningham KA, Bolinger AA, Anastasio NC, "Novel heterocyclic compounds as serotonin (5-ht) 5-ht2a and 5-ht2c receptor positive allosteric modulators.", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Board of Regents of the University of Texas System

[1]

[2]

[3]

[4]

CTW0404

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Identifiers

IUPAC name (2S,4R)-N-(2-morpholin-4-ylethyl)-4-(2-phenylethyl)piperidine-2-carboxamide
PubChem CID	156012687
ChemSpider	129472747
ChEMBL	ChEMBL4637675
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₀H₃₁N₃O₂
Molar mass	345.487 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN[C@@H](C[C@@H]1CCC2=CC=CC=C2)C(=O)NCCN3CCOCC3
InChI InChI=1S/C20H31N3O2/c24-20(22-10-11-23-12-14-25-15-13-23)19-16-18(8-9-21-19)7-6-17-4-2-1-3-5-17/h1-5,18-19,21H,6-16H2,(H,22,24)/t18-,19+/m1/s1 Key:YQSGRDPBXKGAPX-MOPGFXCFSA-N

CTW0404

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