MS-245

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MS-245
Clinical data
ATC code
  • none
Identifiers
  • 2-[5-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl]-N,N-dimethylethanamine
CAS Number
PubChem CID
ChemSpider
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC19H22N2O3S
Molar mass358.46 g·mol−1
3D model (JSmol)
  • COc2cc1c(CCN(C)C)cn(c1cc2)S(=O)(=O)c3ccccc3
  • InChI=1S/C19H22N2O3S/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17/h4-10,13-14H,11-12H2,1-3H3
  • Key:AIJIQCBYMBZLJD-UHFFFAOYSA-N
  (verify)

MS-245 is a tryptamine derivative used in scientific research. It acts as a selective 5-HT6 receptor antagonist with a Ki of 2.3 nM, and was derived through structure-activity relationship development of the selective 5-HT6 agonist EMDT.[1] It has been used as a lead compound for further development of tryptamine-derived 5-HT6 antagonists.[2][3] In animal studies it has been shown to boost the activity of, but not substitute for, both amphetamine and nicotine.[4][5]

See also

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References

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