Eltoprazine

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Eltoprazine
Clinical data
Other namesDU-28,853; DU-28853
ATC code
  • None
Identifiers
  • 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC12H16N2O2
Molar mass220.272 g·mol−1
3D model (JSmol)
  • C1CN(CCN1)C2=C3C(=CC=C2)OCCO3
  • InChI=1S/C12H16N2O2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13H,4-9H2
  • Key:WVLHGCRWEHCIOT-UHFFFAOYSA-N

Eltoprazine (developmental code name DU-28,853) is a serotonergic drug of the phenylpiperazine class which is described as a serenic, or anti-aggressive agent.[1][2][3]

It acts as an agonist of the serotonin 5-HT1A and 5-HT1B receptors and as an antagonist of the serotonin 5-HT2C receptor.[3][4] The drug is closely related to fluprazine and batoprazine, which are similarly acting agents, and is also a known chemical precursor to S-15535 and lecozotan.

Eltoprazine was first described in the scientific literature by 1987.[5][6] It is or was under development for the treatment of aggression, attention deficit hyperactivity disorder (ADHD), cognitive disorders, and drug-induced dyskinesia, but no recent development has been reported for these indications as of February 2022.[1] It was also under development for the treatment of psychotic disorders, but development for this indication was discontinued.[1] Eltoprazine is said to have shown signs of effectiveness for treatment of aggression, but was rejected for marketing authorization on the basis of the fact that aggression is a symptom rather than a disorder.[7][8] The drug was originated by Solvay and was developed by Elto Pharma, PsychoGenics, and Solvay.[1]

See also

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References

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  5. ^ Olivier, B., Mos, J., Heyden, V. D. J. A., Zethof, T., Aken, V. H., Oorschot, V. R., & Ramirez, J. M. (1987). Effects of DU 28853, a new serenic drug, in several experimental models for aggression. Research on Aggression, 93. https://scholar.google.com/scholar?cluster=5474933454486255245
  6. ^ Schipper, J., Olivier, B., Mos, J., Tulp, M. T. M., Sijbesma, H., & Bevan, P. (1987). Eltoprazine (DU 28853): Effects on aggressive behaviour and its serotonergic properties. In International Conference on the Behavioral Pharmacology of [...]. https://scholar.google.com/scholar?cluster=17685819389699199278
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  • Error creating thumbnail: File missing Media related to Lua error in Module:Commons_link at line 62: attempt to index field 'wikibase' (a nil value). at Wikimedia Commons
  • Eltoprazine - AdisInsight
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