Pertine

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Chemical structure of oxypertine, the most well-known drug of the pertine group.

The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs:[1][2]

Oxypertine is known to show high affinity for the serotonin 5-HT2 and dopamine D2 receptors (Ki = 8.6 nM and 30 nM, respectively) and to also act as a catecholamine depleting agent.[2][3] Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals.[2][4]

Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety.[1][2]

The pertines were developed and initially described in the 1960s and 1970s.[1]

See also

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References

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