SN-22

SN-22
Clinical data
Drug class	Serotonin receptor agonist
Identifiers
	IUPAC name 3-(1-methylpiperidin-4-yl)-1H-indole;
CAS Number	17403-07-5 [pubchem];
PubChem CID	11206672;
ChemSpider	9381734 ;
UNII	7NSM99C49F;
ChEMBL	ChEMBL341485;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C14H18N2
Molar mass	214.312 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCC(CC1)c1c[nH]c2c1cccc2;
	InChI InChI=1S/C14H18N2/c1-16-8-6-11(7-9-16)13-10-15-14-5-3-2-4-12(13)14/h2-5,10-11,15H,6-9H2,1H3; Key:KYSCKYJNMTUJPA-UHFFFAOYSA-N;

SN-22 is a piperidinylindole which acts as a moderately selective agonist at the 5-HT₂ family of serotonin receptors, with a K_i of 19 nM at 5-HT₂ subtypes versus 514 nM at 5-HT_1A receptors.^[1]^[2] Many related derivatives are known, most of which are ligands for 5-HT_1A, 5-HT₆ or dopamine D₂ receptors or show SSRI activity.^[3]^[4]^[5]^[6]^[7]

References

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^ US 6046215, "Inhibition of serotonin reuptake"

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