Tofenacin

Tofenacin
	File:Tofenacin.svg
Clinical data
Trade names	Elamol, Tofacine, Tofalin
Other names	tofenacin hydrochloride (USAN US)
Routes of; administration	By mouth
ATC code	None;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name N-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine;
CAS Number	15301-93-6 ; 10488-36-5 (HCl);
PubChem CID	25315;
ChemSpider	23647;
UNII	C4A112M10H;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C17H21NO
Molar mass	255.361 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(CCNC)C(c1ccccc1)c2ccccc2C;
	InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3; Key:PNYKGCPSFKLFKA-UHFFFAOYSA-N;

Tofenacin is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the United Kingdom and Italy in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part of Astellas Pharma).^[1]^[2]^[3] It acts as a serotonin-norepinephrine reuptake inhibitor,^[4] and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.^[5]^[6]

References

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