AEBP2
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Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter[1] of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).[2]
Function
[edit | edit source]AEBP2 is a DNA-binding transcriptional repressor. It may interact with and stimulate the activity of the PRC2 complex.[3]
AEBP2 may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.[4]
Clinical significance
[edit | edit source]Diseases associated with AEBP2 include Waardenburg's syndrome, and Hirschsprung's disease.[4]
References
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External links
[edit | edit source]- Human AEBP2 genome location and AEBP2 gene details page in the UCSC Genome Browser.
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