Transcription factor II E
(Redirected from TFIIE)
| general transcription factor IIE, polypeptide 1, alpha 56kDa | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GTF2E1 | ||||||
| Alt. symbols | TF2E1 | ||||||
| NCBI gene | 2960 | ||||||
| HGNC | 4650 | ||||||
| OMIM | 189962 | ||||||
| RefSeq | NM_005513 | ||||||
| UniProt | P29083 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q21-q24 | ||||||
| |||||||
| general transcription factor IIE, polypeptide 2, beta 34kDa | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GTF2E2 | ||||||
| Alt. symbols | TF2E2 | ||||||
| NCBI gene | 2961 | ||||||
| HGNC | 4651 | ||||||
| OMIM | 189964 | ||||||
| RefSeq | NM_002095 | ||||||
| UniProt | P29084 | ||||||
| Other data | |||||||
| Locus | Chr. 8 p12 | ||||||
| |||||||
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.[2]
TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.[2] Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes.[3][4][5][6] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[7]
See also
[edit | edit source]References
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External links
[edit | edit source]- Transcription+Factor+TFIIE at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
