Pelanserin

Pelanserin
Names
	Preferred IUPAC name 3-[3-(4-Phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione
	Other names TR2515
Identifiers
CAS Number	2208-51-7 ;
3D model (JSmol)	Interactive image;
ChemSpider	58898;
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PubChem CID	65435;
UNII	6SNR96E409 ;
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	InChI InChI=1S/C21H24N4O2/c26-20-18-9-4-5-10-19(18)22-21(27)25(20)12-6-11-23-13-15-24(16-14-23)17-7-2-1-3-8-17/h1-5,7-10H,6,11-16H2,(H,22,27) Key: WPKPLSFHHBBLRY-UHFFFAOYSA-N; InChI=1/C21H24N4O2/c26-20-18-9-4-5-10-19(18)22-21(27)25(20)12-6-11-23-13-15-24(16-14-23)17-7-2-1-3-8-17/h1-5,7-10H,6,11-16H2,(H,22,27) Key: WPKPLSFHHBBLRY-UHFFFAOYAV;
	SMILES C1CN(CCN1CCCN2C(=O)C3=CC=CC=C3NC2=O)C4=CC=CC=C4;
Properties
Chemical formula	C21H24N4O2
Molar mass	364.449 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Pelanserin (TR2515) is a chemical compound that acts as an antagonist of the 5-HT₂ and α₁-adrenergic receptors.^[1]

Synthesis

Pelanserin (3) can be synthesized by a reaction between isatoic anhydride (1) and 1-(3-aminopropyl)-4-phenylpiperazine (2) in the presence of phosgene.^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]

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^ AT 269143B, "Verfahren zur Herstellung von neuen Chinazolindionderivaten und ihrer Säureadditionssalze bzw. ihrer entsprechenden Piperaziniumverbindungen [Process for the preparation of new quinazolinedione derivatives and their acid addition salts or their corresponding piperazinium compounds]", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to Miles Laboratories, Inc.
^ Hayao Shin, U.S. patent 3,274,194 (1966 to Bayer Corp)
^ Horacio Vidrio, U.S. patent 3,919,425 (1975 to Bayer Corp).

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