7-Hydroxy-DMT

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7-Hydroxy-DMT
Clinical data
Other names7-HO-DMT; 7-OH-DMT; 7-Hydroxy-N,N-dimethyltryptamine
Drug classSerotonin receptor modulator
ATC code
  • None
Identifiers
  • 3-[2-(dimethylamino)ethyl]-1H-indol-7-ol
CAS Number
PubChem CID
ChemSpider
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC12H16N2O
Molar mass204.273 g·mol−1
3D model (JSmol)
  • CN(C)CCC1=CNC2=C1C=CC=C2O
  • InChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-12-10(9)4-3-5-11(12)15/h3-5,8,13,15H,6-7H2,1-2H3
  • Key:FZFHBMMTKKWEQH-UHFFFAOYSA-N

7-Hydroxy-DMT (7-HO-DMT), also known as 7-hydroxy-N,N-dimethyltryptamine, is a serotonin receptor modulator of the tryptamine family related to dimethyltryptamine (DMT).[1][2] It is the 7-hydroxy derivative of DMT and is a positional isomer of psilocin (4-HO-DMT), bufotenin (5-HO-DMT), and 6-HO-DMT.[1][2] The drug shows affinity for serotonin receptors in the rat fundus strip.[1][2] However, it had the lowest serotonin receptor affinity of any other assessed compounds in a series of assessed tryptamines.[1][2] In a later study, its affinity (Ki) for the serotonin 5-HT2A receptor was >10,000 nM.[3][4] 7-Hydroxy-DMT is said to be biologically active in animals but to show low potency.[1] The drug was first described in the scientific literature by at least 1962.[5][6]

See also

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References

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