Sabcomeline
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| File:Sabcomeline skeletal.svg | |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
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| Formula | C10H15N3O |
| Molar mass | 193.250 g·mol−1 |
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Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease.[1] It made it to phase III clinical trials before being discontinued due to poor results.
It is a non-selective agonist of all five muscarinic acetylcholine receptors with similar affinities.[2] However, functional selectivity for the M1 receptor has been claimed in vitro and in vivo.[2]