Talastine

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Talastine
File:Talastine.png
Clinical data
ATC code
Identifiers
  • 4-benzyl-2-[2-(dimethylamino)ethyl]phthalazin-1(2H)-one
CAS Number
PubChem CID
ChemSpider
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC19H21N3O
Molar mass307.397 g·mol−1
3D model (JSmol)
  • O=C1c3ccccc3\C(=N/N1CCN(C)C)Cc2ccccc2
  • InChI=1S/C19H21N3O/c1-21(2)12-13-22-19(23)17-11-7-6-10-16(17)18(20-22)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3 checkY
  • Key:LCAAMXMULMCKLJ-UHFFFAOYSA-N checkY
  (verify)

Talastine (trade name Ahanon) is an antihistamine.[1]

Synthesis

[edit | edit source]

The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with dimethylaminoethyl chloride.[2][3]

References

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  1. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  2. ^ DE 1046625, Engelbrecht, et al., issued Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to VEB Deutsches Hydrierwerk Rodleben 
  3. ^ US 3017411, Engelbrecht, et al., issued Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to VEB Deutsches Hydrierwerk Rodleben 
[edit | edit source]
  • Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  • Talastine at the U.S. National Library of Medicine Medical Subject Headings (MeSH)