Platelet-activating factor receptor
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The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor.[1][2] It is encoded in the human by the PTAFR gene.
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][3] Its pathogenetic role in chronic kidney failure has also been reported recently.[4]
Ligands
[edit | edit source]Agonists
Antagonists
- Apafant (WEB-2086)
- Israpafant (Y-24180)
- Lexipafant
- Rupatadine
References
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Further reading
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External links
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- platelet+activating+factor+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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