Frizzled-8
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.[1][2]
Function
[edit | edit source]This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]
References
[edit | edit source]Further reading
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External links
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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