GPR6
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[1][2]
Function
[edit | edit source]GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[3]
GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[4]
Ligand
[edit | edit source]Inverse Agonist
[edit | edit source]- Cannabidiol[5]
- Solangepras (solengepras; CVN-424)
Evolution
[edit | edit source]Paralogues to GPR6 gene
[edit | edit source]Source:[6]
- GPR3
- GPR12
- S1PR5
- S1PR1
- CNR1
- S1PR2
- LPAR2
- CNR2
- MC1R
- S1PR3
- S1PR4
- GPR119
- MC3R
- MC4R
- MC5R
- LPAR1
- LPAR3
- MC2R
See also
[edit | edit source]References
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- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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External links
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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