The MAS1 oncogene (MAS receptor) is a G protein-coupled receptor[1][2] which binds the angiotensin II metabolite angiotensin (1-7).[3][4] The MAS1 receptor, when activated by binding angiotensin-(1-7), opposes many of the effects of the angiotensin II receptor. Hence, MAS1 receptor agonists have similar therapeutic effects to angiotensin II receptor antagonists, including lowering of blood pressure.[5]
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