Frizzled-7
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.[1][2][3]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]
Interactions
[edit | edit source]Fz-7 has been shown to interact with DLG4.[4]
References
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Further reading
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External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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