Neurotensin receptor 2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]
Function
[edit | edit source]The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.[3] Binding and pharmacological studies demonstrate that this receptor binds Neurotensin (NT) as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a neuromodulator of dopamine and has hypothermic and analgesic properties in the brain and some peripheral organ function as well.[4] NTS2 is found mostly in the brain through Northern-blot analysis.[4]Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.[4]
See also
[edit | edit source]References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links
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