GPR124
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[1][2][3] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4][5][6]
Interactions
[edit | edit source]GPR124 has been shown to interact with DLG1[7] and is involved in the Wnt/β-catenin signaling pathway along with RECK.[8] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain.[9] GPR124 (ADGRA2) was predicted using SSHHPS.
Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.
References
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Further reading
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