Alpha-2A adrenergic receptor
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2-adrenergic receptor, and also denotes the human gene encoding it.[1]
Receptor
[edit | edit source]α2-adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α2A and α2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α2C subtype modulated neurotransmission at lower levels of nerve activity.[2]
Gene
[edit | edit source]This gene encodes α2A subtype and it contains no introns in either its coding or untranslated sequences.[1]
Ligands
[edit | edit source]Agonists
[edit | edit source]Antagonists
[edit | edit source]- Atipamezole
- Idazoxan
- 1-PP (active metabolite of buspirone and gepirone)
- Asenapine
- BRL-44408
- Clozapine
- Lurasidone
- Mianserin
- Mirtazapine
- Paliperidone
- Risperidone
- Yohimbine
See also
[edit | edit source]References
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Further reading
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External links
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- Human ADRA2A genome location and ADRA2A gene details page in the UCSC Genome Browser.
- Human ZNF32 genome location and ZNF32 gene details page in the UCSC Genome Browser.
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