SPT-348

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SPT-348
Clinical data
Other namesSPT348
Drug classNon-hallucinogenic psychoplastogen; Non-selective serotonin receptor modulator; Non-hallucinogenic serotonin 5-HT2A receptor partial agonist
ATC code
  • None
Identifiers
E number{{#property:P628}}
CompTox Dashboard (EPA)
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SPT-348 is a serotonin receptor modulator and non-hallucinogenic psychoplastogen of the lysergamide family which is under development for the treatment of depression, anxiety, and other neuropsychiatric disorders.[1][2][3][4] It is a prodrug of 2-bromo-LSD (bromolysergide; BOL-148), a non-selective serotonin receptor modulator and partial agonist of the serotonin 5-HT2A receptor,[5][6] and is an analogue of the serotonergic psychedelic LSD.[3][4] The drug is said to employ a novel formulation involving a triglyceride linker that helps it to bypass first-pass metabolism in the liver that is said to be prominent with LSD.[2] As of 2025, SPT-348 is in the discovery or preclinical research stage of development.[2][1]

See also

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References

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