SCQ1

SCQ1

File:SCQ1 structure.png
Identifiers
IUPAC name (S)-spiro[4-azabicyclo[2.2.2]octane-2,2'-benzo[h]chromen]-4'(3'H)-one
ChemSpider	88790995
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H19NO2
Molar mass	293.366 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C3C[C@@]1(CN2CCC1CC2)Oc4c3ccc5ccccc45

(S)-SCQ1 is a drug which acts as a potent and selective antagonist for the 5-HT_2B and 5-HT_2C serotonin receptors, but with only modest affinity for the closely related 5-HT_2A receptor and other targets such as 5-HT₇. Since most currently available 5-HT₂ class ligands have relatively poor selectivity and bind to all three subtypes, the selectivity of (S)-SCQ1 is expected to be useful for studying 5-HT_2A receptor mediated responses in the absence of 5-HT_2B and 5-HT_2C activation.

See also

• SB-206553
• SB-242,084
• Z3517967757