Methylatropine

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Methylatropine
File:Methylatropine.png
Clinical data
Trade namesEumydrin
Other namesMethylatropinium; Methyl atropine; Methyl atropine nitrate; Methylatropine nitrate; Atropine methyl nitrate
ATC code
Identifiers
  • (1R,5R)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC18H26NO3
Molar mass304.410 g·mol−1
3D model (JSmol)
  • C[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C
  • InChI=1S/C18H26NO3/c1-19(2)14-8-9-15(19)11-16(10-14)22-18(21)17(12-20)13-6-4-3-5-7-13/h3-7,14-17,20H,8-12H2,1-2H3/q+1/t14-,15+,16?,17-/m0/s1
  • Key:PIPAJLPNWZMYQA-WFVVYAPDSA-N
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Methylatropine, sold under the brand name Eumydrin, is a belladonna derivative.[1]

In 1902, the Bayer Company introduced methylatropine, a quaternary ammonium salt of atropine, as a mydriatic for dilation of the pupil during ophthalmic examination under the brand name of Eumydrin. Because of its highly polar nature it penetrated less readily into the central nervous system than did atropine; hence it was introduced for relieving pyloric spasm in infants.[2]

The blocking potency of methylatropine is approximately 10-20 times higher than that of atropine at neuromuscular and ganglionic synapses.[3]

See also

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References

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