Camylofin
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| Other names | Acamylophenine |
| AHFS/Drugs.com | International Drug Names |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C19H32N2O2 |
| Molar mass | 320.477 g·mol−1 |
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Camylofin is an antimuscarinic drug.[1]
Camylofin is a smooth muscle relaxant with both anticholinergic action and direct smooth muscle action. Anticholinergic action is produced by inhibiting the binding of acetylcholine to muscarinic receptors, but the action is less pronounced.[citation needed] Direct smooth muscle relaxation is achieved by inhibiting phosphodiesterase type IV, which leads to increased cyclic AMP and eventually reduced cytosolic calcium. Thus camylofin has a comprehensive action to relieve smooth muscle spasm. It is used to treat stomach ache in infants and children. Usually it is given in combination with paracetamol to treat stomach ache, as well as pyrexia.[2]
Synthesis
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The Hell–Volhard–Zelinsky halogenation on phenylacetic acid [103-82-2] (1) gives 2-Bromo-2-phenylacetyl bromide, CID:15621041 (2). Treatment with isoamyl alcohol [123-51-3] gives 3-methylbutyl bromo(phenyl)acetate [92018-48-9] (3). Alkylation with N,N-Diethylethylenediamine [100-36-7] (4) completed the synthesis of Camylofin (5).
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Bruzzese, Tiberio; Crescenzi, Elda (1966). "N-Aminoalkyl-α-aminoacids and Their Corresponding Ethyl Esters". Journal of Pharmaceutical Sciences. 55 (7): 737–740. doi:10.1002/jps.2600550717.
- ^ Szarvasi, E. et al, Bull. Soc. Chim. Fr., 1957, 1019.
- ^ Brock Norbert, Kuhas Engelbert, & Schmeisser Martin, U.S. patent 2,665,300 (1954 to Asta Medica AG).
- ^ Martin Dr-Chem Schmeisser, Engelbert Dr Phil Kuehas, Norbert Dr Med Brock, DE842206 (1952 to Asta Werke Ag Chem Fab).
- ^ , GB688331 (1953 to Asta Medica AG).
- ^ , GB782068 (1957 to Asta Medica AG).
- ^ Kuhas Engelbert, Brock Norbert, & Arnold Herbert, CA566251 (1958 to Asta Medica AG).
- ^ Arnold Herbert, Kuhas Engelbert, & Brock Norbert, U.S. patent 2,857,395 (1958).