3-APPA

3-Aminopropylphosphinic acid
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Clinical data
Other names	3-APPA, CGP 27492
ATC code	None;
Identifiers
	IUPAC name 3-aminopropylphosphinic acid;
CAS Number	103680-47-3 check;
PubChem CID	121956;
IUPHAR/BPS	1081;
ChemSpider	10462431;
UNII	QMT5SS3QRE;
ChEMBL	ChEMBL112203;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C3H10NO2P
Molar mass	123.092 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CN)CP(=O)O;
	InChI InChI=1S/C3H10NO2P/c4-2-1-3-7(5)6/h7H,1-4H2,(H,5,6); Key:ZTHNRNOOZGJLRR-UHFFFAOYSA-N;

3-Aminopropylphosphinic acid, also known in the literature as 3-APPA or CGP 27492,^[1] is a compound used in scientific research which acts as an agonist at the GABA_B receptor. It is part of a class of phosphinic acid GABA_B agonists,^[2] which also includes SKF-97,541. It has a binding affinity (pK_i) to the GABA_B receptor of 8.30 (i.e., ~3 nM).^[3]

References

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[1]

[2]

[3]

3-APPA

References

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