Iso-THIP
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| File:Iso-THIP.svg | |
| Clinical data | |
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| Other names | IsoTHIP; Isogaboxadol |
| Drug class | GABAA-ρ receptor antagonist; GABAA receptor antagonist |
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| CAS Number | |
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| ChemSpider | |
| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C6H8N2O2 |
| Molar mass | 140.142 g·mol−1 |
| 3D model (JSmol) | |
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Iso-THIP, or isoTHIP, is a selective and potent GABAA-ρ receptor (GABAC receptor) antagonist related to gaboxadol (THIP).[1][2][3] It is 4-fold more potent than gaboxadol as a GABAA-ρ receptor antagonist.[2][3] In addition to its GABAA-ρ receptor antagonism, iso-THIP shows much lower but still detectable affinity for the GABAA receptor, where it appears to be an antagonist similarly.[2][3][4] The drug was first described in the scientific literature by Povl Krogsgaard-Larsen and colleagues by 1979.[4][5]
See also
[edit | edit source]References
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