CGP-35348

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CGP-35348
File:CGP-35348.svg
Identifiers
  • 3-Aminopropyl(diethoxymethyl)phosphinic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC8H20NO4P
Molar mass225.225 g·mol−1
3D model (JSmol)
  • CCOC(OCC)P(=O)(CCCN)O
  • InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11) ☒N
  • Key:QIIVUOWTHWIXFO-UHFFFAOYSA-N ☒N
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CGP-35348 is a compound used in scientific research which acts as an antagonist at GABAB receptors.[1][2][3]

CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing so selectively as a GABAB heteroreceptor antagonist. [4] Moreover, CGP-35348 was about threefold less potent in antagonizing gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) than baclofen and SKF-97,541.[5]

References

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