Gabamide

Gabamide
	File:4-Aminobutyramide.png
Clinical data
Other names	GABAmide; GABAMIDE; GABA amide; 4-Aminobutanamide; 4-ABAD; 4-Aminobutyramide; gamma-Aminobutyramide; γ-Aminobutyramide; GABAD; gamma-Aminobutyric acid amide; γ-Aminobutyric acid amide
Drug class	GABA receptor agonist
ATC code	None;
Identifiers
	IUPAC name 4-aminobutanamide;
CAS Number	3251-08-9;
PubChem CID	18615;
ChemSpider	17581;
UNII	DQN3YXP96S;
ChEMBL	ChEMBL1199935;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C4H10N2O
Molar mass	102.137 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CC(=O)N)CN;
	InChI InChI=1S/C4H10N2O/c5-3-1-2-4(6)7/h1-3,5H2,(H2,6,7); Key:WCVPFJVXEXJFLB-UHFFFAOYSA-N;

Gabamide, or GABAmide, also known as γ-aminobutyramide (GABAD), is a GABA receptor agonist and GABA analogue, or more specifically the amide of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).^[1]^[2] Along with GABA and progabide acid (SL-75.102), gabamide is an active metabolite of the anticonvulsant drug progabide (Gabrene; SL-76.002).^[1]^[2] Unlike progabide, but similarly to GABA, gabamide is unable to cross the blood–brain barrier and hence is peripherally selective.^[2] However, gabamide and GABA are formed in the brain from progabide following its entry into this part of the body.^[2]

References

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