Aza-THIP

Aza-THIP
	File:Aza-THIP.svg
Clinical data
Other names	Azagaboxadol
Drug class	GABAA-ρ antagonist
ATC code	None;
Identifiers
	IUPAC name 1,2,4,5,6,7-hexahydropyrazolo[3,4-c]pyridin-3-one;
CAS Number	654666-65-6;
PubChem CID	55285412;
ChemSpider	27267416;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C6H9N3O
Molar mass	139.158 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CNCC2=C1C(=O)NN2;
	InChI InChI=1S/C6H9N3O/c10-6-4-1-2-7-3-5(4)8-9-6/h7H,1-3H2,(H2,8,9,10); Key:UPMMUUFLHUEUKP-UHFFFAOYSA-N;

Aza-THIP is a selective and moderately potent GABA_A-ρ (GABA_C receptor) antagonist related to gaboxadol (THIP).^[1]^[2]^[3]^[4] Unlike gaboxadol, it is virtually inactive at the GABA_A receptor.^[1]^[2]^[4]^[5] The drug was first described in the scientific literature by Povl Krogsgaard-Larsen and colleagues by 1979.^[6]^[7]

References

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