XAP044

XAP044
Identifiers
	IUPAC name 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;
CAS Number	196928-50-4 ;
PubChem CID	5428913;
IUPHAR/BPS	8545;
ChemSpider	4558326;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C15H9IO4
Molar mass	380.137 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I;
	InChI InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H; Key:XXZKJJYWINSUMJ-UHFFFAOYSA-N;

XAP044 is a drug which acts as a potent and selective antagonist of the metabotropic glutamate receptor 7 (mGluR₇). It inhibits long-term potentiation in the amygdala and inhibits responses associated with stress and anxiety in animal models,^[1] as well as being used to study the role of mGluR₇ in various other processes.^[2]^[3]^[4]

References

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Identifiers

IUPAC name 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
CAS Number	196928-50-4^Y
PubChem CID	5428913
IUPHAR/BPS	8545
ChemSpider	4558326
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₅H₉IO₄
Molar mass	380.137 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
InChI InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H Key:XXZKJJYWINSUMJ-UHFFFAOYSA-N