ACPD

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ACPD
Stereo, skeletal formula of ACPD ((1S,3S)-1-amino,-1,3-dicarboxylic acid)
Stereo, skeletal formula of ACPD ((1S,3S)-1-amino,-1,3-dicarboxylic acid)
Names
Preferred IUPAC name
1-Aminocyclopentane-1,3-dicarboxylic acid[1]
Identifiers
3D model (JSmol)
Abbreviations ACPD
ChEMBL
ChemSpider
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MeSH 1-amino-1,3-dicarboxycyclopentane
RTECS number
  • GY4060000 (1S,3R)
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  • InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12) ☒N
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  • NC1(CCC(C1)C(O)=O)C(O)=O
Properties
C7H11NO4
Molar mass 173.168 g·mol−1
Appearance White crystals
20 g dm−3
Solubility in ethanol 240 mg dm−3
log P −0.709
Acidity (pKa) 2.112
Basicity (pKb) 11.885
Isoelectric point 2.84
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302, H312, H315, H319, H332, H335
P261, P280, P305+P351+P338
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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1-Amino-1,3-dicarboxycyclopentane (ACPD) is a chemical compound that binds to the metabotropic glutamate receptor (mGluR),[2] acting as a mGluR agonist. ACPD is a rigid analogue of the neurotransmitter glutamate and does not activate ionotropic glutamate receptors.[3] However, it has been reported to be an agonist of the glycine site of the NMDA receptor.[citation needed] ACPD can induce convulsions in neonatal rats.[4]

References

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