Oxycodone/paracetamol
| Combination of | |
|---|---|
| Oxycodone | Opioid analgesic |
| Acetaminophen | Anilide analgesic |
| Clinical data | |
| Trade names | Percocet, others |
| AHFS/Drugs.com | |
| License data | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| ChemSpider | |
| KEGG | |
| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| ☒check (what is this?) (verify) | |
Oxycodone/paracetamol, sold under the brand name Percocet among others,[2] is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.[1]
In 2023, it was the 93rd most commonly prescribed medication in the United States, with more than 7 million prescriptions.[3][4]
History
[edit | edit source]The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.[5]
Society and culture
[edit | edit source]Percocet is often called perc for short.[6][7] Since the early 2010s, the medication has commonly been name-dropped in songs from multiple genres, such as Future's 2017 song "Mask Off".[6]
Implicated in deaths
[edit | edit source]In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[8] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.[9]
In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007; this led to a doubling of all opioid-related deaths in Ontario over the same period.[10][11][12]
References
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